Fortifeye Next Gen Zinc Free Macular Defense Capsules
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Fortifeye Next Gen Zinc Free Macular Defense Capsules

$57.00 available on subscription

(19 customer reviews)

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Introducing Fortifeye Next Gen Zinc Free Macular Defense, a revolutionary product that represents the outcome of extensive research, incorporating the latest evidence-based scientific findings. This cutting-edge formula provides advanced nutritional support for both your eyes and overall well-being. To experience its benefits, it is recommended to take 3 capsules daily, preferably with food.

Fortifeye Next Gen Zinc Free Macular Defense, the latest in nutritional support designed for overall well-being and optimal eye health. Fortifeye Vitamins has meticulously incorporated the latest evidence-based research from clinical studies to create a groundbreaking multivitamin/eye vitamin combination. By focusing on the macula, Fortifeye has revolutionized their previous Fortifeye Zinc Free Macular Defense, transforming it into this new generation multivitamin/eye vitamin blend. Now available in easy-to-swallow vegetarian capsules, this cost-effective Nutraceutical offers cutting-edge nutrition for complete body wellness and vision support. With thousands of patients worldwide taking  Fortifeye Vitamins, the Next Gen Zinc Free Macular Defense formula has been exclusively available through select eye care centers for the past two years. It is with great pleasure that we announce its availability to the general public.

In response to recent scientific findings, Fortifeye Vitamins has introduced a zinc-free antioxidant eye vitamin specifically designed for individuals with macular degeneration. The latest studies indicate that certain genotypes of the population affected by macular degeneration may experience adverse effects from zinc supplementation, while others may benefit from a combination of zinc and antioxidants. This new formulation aims to address these varying genetic factors and provide a tailored approach to support macular degeneration patients without the inclusion of zinc. These nutraceuticals have been developed to promote overall body wellness, bolster the immune system, and provide comprehensive vision support. Fortifeye Next Gen Zinc Free Macular Defense simplifies your regimen with a single capsule to be taken three times a day alongside meals or as recommended by your optometrist or ophthalmologist.

To determine the appropriate nutritional regimen for macular degeneration patients, it is recommended to undergo a genetic DNA test specifically for macular degeneration. This simple in-office test enables eye care providers to identify the patient’s specific genetic profile and customize their nutritional approach accordingly. By implementing genotype-directed nutritional therapy, improved outcomes can be expected for many individuals with macular degeneration. DNA testing should now be considered the gold standard in determining the suitable supplement for each patient. Nutritional experts recommend a daily zinc intake of no more than 40mg.

Fortifeye’s doctors have provided specific recommendations regarding the usage of Zinc-Free Macular Defense and Macular Defense based on different circumstances:

1. If a DNA test conducted by your eye care provider indicates that zinc could potentially be harmful to your macular, it is advised to opt for the Zinc-Free Macular Defense.

2. Individuals who consume animal proteins regularly throughout the day generally obtain sufficient zinc from their diet and are recommended to take the Zinc-Free Macular Defense.

3. Vegans, those following a plant-based diet, or individuals with minimal animal protein intake should opt for the Macular Defense, which contains some zinc.

4.  Alcoholics are advised to take Macular Defense, as they typically require additional zinc supplementation.

5. Patients with digestive issues such as Crohn’s disease and ulcerative colitis may require higher levels of zinc, making Macular Defense the preferred choice over the Zinc-Free Macular Defense.

6.  Individuals taking diuretics may benefit from the zinc content in Macular Defense, making it the recommended option instead of the Zinc-Free Macular Defense.

It is important to consult with your healthcare provider or eye care professional to determine the most suitable supplement based on your specific circumstances and needs.

Manufactured in an FDA-inspected facility with NSF certification, this supplement employs USP-certified ingredients. The formulation of this unique new blend is rooted in the latest scientific research and is currently being utilized by numerous individuals dealing with macular degeneration. After nearly two decades of research and fourteen reformulations, the nutrient profile of this supplement has evolved to its current state. The final formula was meticulously refined through extensive clinical use with patients in prominent eye care centers, complemented by serum and intracellular blood testing and retesting.

This new formula incorporates some of the most recent evidence-based nutrients renowned for their visual support and overall health benefits. These include B Complex, eight variations of Vitamin E, D3, C, Saffron, resveratrol, pine bark extract, black currant fruit extract, lutein, zeaxanthin, astaxanthin, grape seed extract, coenzyme Q10, taurine, acetyl l carnitine, alpha-lipoic acid, bilberry, and curcumin derived from the turmeric root. These nutrients possess potent antioxidant and anti-inflammatory properties, which may also help inhibit the formation of detrimental blood vessels (anti-VEGF). The formula incorporates clinically studied levels of Vitamins D, E, C, B, and chromium. These ingredients provide nutritional support for many eye and systemic health conditions.

In a comprehensive cardiovascular disease trial spanning seven years and involving over 5,200 women, a daily regimen of folic acid, B-6, and B-12 was administered to half of the participants, while the other half received a placebo. The group receiving the vitamin supplementation experienced a remarkable 41% reduction in the occurrence of macular degeneration. This discovery holds significant implications for both individuals suffering from macular degeneration and their family members. While further research is required, incorporating B complex into one’s diet may prove beneficial in the support of the retina and overall bodily health. Additionally, some early studies suggest that B12 may offer protective benefits against conditions such as cataracts, glaucoma, and optic neuropathy. Insufficient levels of B12 have been associated with memory problems, dementia, and Alzheimer’s disease. Furthermore, B12, Folic Acid, and B6 are utilized to lower homocysteine levels, thereby reducing the risk of potential health problems related to elevated homocysteine.

This formula incorporates Lutein and Zeaxanthin isomers within an innovative microbeadlet delivery system. These components play a vital role in replenishing macular pigment density, offering protection against harmful blue light, and serving as potent antioxidants to counteract free radicals. Scientific research suggests that macular pigment density gradually diminishes as macular degeneration advances. Lutein and Zeaxanthin are demonstrating their efficacy in the nutritional support of the macula.  Furthermore, studies exploring the effects of these carotenoids reveal their potential benefits for skin health and cognitive function.

To promote the health of mitochondria, the organelles responsible for ATP (energy) production, as well as provide neuroprotection, this formula includes (Acetyl L Carnitine, Alpha Lipoic Acid, Astaxanthin, and CoQ10. Furthermore, all eight forms of vitamin E our tocopherols and four tocotrienols) are incorporated to optimize the neutralization of free radicals.

Resveratrol, a potent polyphenol predominantly found in red wine, exhibits remarkable antioxidant and anti-inflammatory properties. The “French Paradox” highlights the correlation between the French population, who consume diets high in saturated fats, and their lower rates of heart disease and mortality compared to Americans. This phenomenon is attributed, in part, to the potential protective effects of resveratrol found in the red wine they regularly consume. Resveratrol has been associated with promoting healthy aging. Numerous studies have demonstrated potential benefits of resveratrol for various health conditions. Recent research indicates that resveratrol may positively influence conditions such as macular degeneration, cataracts, glaucoma, and proliferative diabetic retinopathy. Fortifeye was among the pioneers in utilizing resveratrol in their supplements, recognizing its potential early on within the industry.

Incorporated for its exceptional ability to neutralize free radicals and reduce inflammation, Astaxanthin provides remarkable benefits. Compared to vitamin C, Astaxanthin is an astounding 550 times more potent in quenching free radicals.

Astaxanthin naturally occurs in the ciliary body of the eye and has been associated with reduced eye strain and improved accommodation. Studies suggest that Astaxanthin also enhances choroidal circulation, promoting better blood flow to the eye. Moreover, Astaxanthin has been the subject of multiple studies showcasing its potential to minimize fine lines and wrinkles, leading to improved skin appearance. Additionally, it has been linked to enhanced muscle endurance and faster muscle recovery. Notably, Astaxanthin is responsible for the vibrant red color seen in wild Alaskan salmon.

The inclusion of Saffron in this formula is noteworthy, as it is recognized as the most expensive spice globally, boasting remarkable health benefits for both overall well-being and ocular health. Recent clinical studies have demonstrated that saffron can enhance visual acuity, with patients experiencing an improvement of two lines in cases of macular degeneration. Additionally, saffron has shown some positive effects on ERG (electroretinogram) measurements. This precious spice contains four exceptional antioxidants: crocin, crocetin, safranal, and kaempferol. Saffron appears to be an extremely safe ingredient, exhibiting significant potential for various health benefits. As a result, many supplements specifically formulated for macular degeneration are now incorporating saffron into their formulations.

Clinical studies have substantiated the beneficial effects of Black Currant Fruit Extract, including improved blood flow to the eye, alleviation of dry eye symptoms, enhanced dark adaptation, and potential slowdown in the progression of visual field loss in glaucoma. Moreover, Black Currant Fruit Extract has been the subject of studies supporting a range of other health benefits.

Pine Bark Extract, a newly added ingredient in Fortifeye Next Gen Zinc Free Macular Defense. This extract is rich in three polyphenols: Procyanidins, Catechins, and Phenolic Acids. These compounds possess potent antioxidant, anti-inflammatory, and antimicrobial properties.

Bilberry, also known as European blueberry, is rich in potent antioxidants called anthocyanins. This remarkable fruit serves as both an antioxidant and an anti-inflammatory agent. Interestingly, fighter pilots used to consume bilberry jam, as they believed it improved their night vision. Numerous patients have reported experiencing reduced eye fatigue and fewer dry eye symptoms while working on digital screens when supplementing with bilberry. Scientific studies have demonstrated that bilberry supports a healthy retina, enhances contrast sensitivity, and improves tear secretion. Notably, when combined with pine bark extract, bilberry has clinically shown to lower intraocular pressure in patients. With its impressive benefits, bilberry makes another excellent addition to Fortifeye Next Gen Macular Defense.

Grape seed extract is abundant in anthocyanins, flavonoids, and oligomeric proanthocyanidins (OPCs), all of which play a crucial role in safeguarding the body against oxidative stress and inflammation. Research on grape seed extract indicates its potential protective effects against cataracts and its ongoing investigation for promoting retinal health.

Taurine, an amino acid, is highly concentrated in essential organs such as the eyes, brain, muscles, and heart. It plays a critical role in supporting the central nervous system, immune system, and overall eye health. Acting as an antioxidant and anti-inflammatory agent, taurine offers valuable protective effects. Furthermore, research suggests that taurine enhances energy levels and improves exercise performance. Studies have also indicated potential benefits of taurine for the eyes, heart, hearing, brain, and liver.

To prioritize safety and address potential risks associated with excessive Vitamin A intake, this new formula does not contain Vitamin A. Additionally, it has been observed that beta carotene, often used as a precursor to Vitamin A, may hinder the absorption of Lutein, Zeaxanthin, and Astaxanthin. Consequently, Fortifeye has made the decision to remove both Vitamin A and beta carotene from the formula.

Instead, this comprehensive formulation incorporates a precise blend of various nutrients in optimal ratios, ensuring maximum cellular absorption. Fortifeye Next Gen Zinc Free Macular Defense can be used alone or in conjunction with Fortifeye Super Omega-3 or Fortifeye Focus to combat free radical damage in both the eyes and the body.

 By combining Fortifeye Vitamins or similar supplements with lifestyle adjustments, dietary modifications and following your doctor’s advice you are becoming pro-active in your current and future health.  Fortifeye Next Gen Zinc Free Macular Defense is highly recommended for individuals seeking to take proactive measures for the future well-being of their eyes and overall health.

Developed to provide comprehensive nutritional support, Fortifeye Next Gen Zinc Free Macular Defense targets specific nutrients in precise ratios to offer valuable support to the eye and visual system.

Fortifeye’s objective with Fortifeye Next Gen Zinc Free Macular Defense is to deliver the latest advancements in nutritional support for the eyes and the entire body. This supplement represents an evolution in nutritional science and will continue to evolve as new scientific discoveries emerge. It provides essential support for nutritional anti-aging, benefiting both the eyes and the entire body.


Doctor Approved

Scientifically Formulated

Thoroughly Tested



Supporting Science

Lutein and Zeaxanthin :

Effects of lutein supplementation in age-related macular degeneration – PMC (

Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration-Neurodegenerative Disease – PubMed (

Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3 – PubMed (

Associations between lutein, zeaxanthin, and age-related macular degeneration: an overview – PubMed (

Lutein and Zeaxanthin Status and Risk of Age-Related Macular Degeneration | IOVS | ARVO Journals

New study on Lutemax 2020 supporting vision featured in experimental eye research journal (

Macular Degeneration DNA studies proving Zinc maybe bad for certain patients.

CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration – PubMed (

Treatment response to antioxidants and zinc based on CFH and ARMS2 genetic risk allele number in the Age-Related Eye Disease Study – PubMed (

Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis – PubMed (

CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation | PNAS

Saffron studies for Macular Degeneration : 

 Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial – PubMed (

A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function – PubMed (

Short-term Outcomes of Saffron Supplementation in Patients with Age-related Macular Degeneration: A Double-blind, Placebo-controlled, Randomized Trial – PubMed (

Pine Bark extract for Macular Degeneration and Glaucoma:

Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary open-angle glaucoma – PubMed (

pycno_eye_health_141202_WEB.pdf (

Study shows pine bark improves circulation, s | EurekAlert!

Pycnogenol®: Mirtogenol® Eye Health Supplement Lowers Intraocular Pressure and Improves Blood Flow


Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights – PMC (

Recent Advances and the Mechanism of Astaxanthin in Ophthalmological Diseases – PMC (

Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study – PubMed (


Scientific evidence for many of the nutrients in Fortifeye Macular Defense:

NIH confirms vitamins do benefit macular degeneration:  NIH study confirms benefit of supplements for slowing age-related macular degeneration | National Institutes of Health (NIH)

Zinc may be good or bad for macular degeneration CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration – PubMed (

Lange Survival Diet recommended for ARMD patients:  The Lange Survival Diet – Dr. Michael Lange (

carotenoids are beneficial for macular degeneration    Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study – PubMed (

Folate and B vitamins for macular degeneration:  Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study – PubMed (

Folate and B12 reduced risk of Macular Degeneration:  Folic Acid, Pyridoxine, and Cyanocobalamin Combination Treatment and Age-Related Macular Degeneration in Women: The Women’s Antioxidant and Folic Acid Cardiovascular Study | Macular Diseases | JAMA Internal Medicine | JAMA Network

Folic acid, B12 and B6 reduce risk of Macular Degeneration:  Folic Acid, Vitamin B6, and Vitamin B12 in Combination and Age-related Macular Degeneration in a Randomized Trial of Women (

Elevated homocysteine and low B12 may be risk for macular degeneration:  Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis – PubMed (

Vitamin D important nutrient for Macular Degeneration:  Vitamin D and Age-Related Macular Degeneration – PubMed (

Vitamin D and ARMD:  Vitamin D Levels May Affect Macular Degeneration Risk (

Bilberry for Macular degeneration:  [Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats] – PubMed (

Alcar( acetyl l carnitine)  for macular degeneration: The aging eye and the role of L-carnitine and its derivatives – PubMed (

COQ-10 for Macular Degeneration: Therapeutic Potential of Co-enzyme Q10 in Retinal Diseases – PubMed (

alpha lipoic acid improves vision in macular degeneration:,with%20age%2Drelated%20macular%20degeneration.

Astaxanthin and eye disease :  Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights (

Taurine and eye disease:  Taurine and oxidative stress in retinal health and disease (

Eye Health Studies:

How To Use

Take 1 capsule 3 times a day with a meal.


How long does it take for me to receive my order?

Typical shipping for USPS packages are 4-6 business days. International and large shipments may vary in shipment time. Free shipping only applies to United States shipments. Free shipping promotions does not apply to international orders.

What is your return and exchange policy?

At Fortifeye we offer full refund if not satisfied with product purchased. Refunds are only applicable for price paid for product, shipping charges are not refundable. We are also not responsible for shipping cost to return product to the address below unless the product was received damaged or the wrong product was received for the order placed. We ask that Returns meet the following requirements:

  • Returned within one week  of the original purchase date.
  • Returns must Include name and/or order number associated with product being returned.
  • When Fortifeye receives the return we will then issue a refund to the card used when the original order was placed. Notification will be sent via E-mail to verify your refund has been completed.
  • Open products are subject to equal value exchange and/or partial refund.
  • Returns to:  Please contact the Nutrition Center for return shipping information. 866-503-9746 or

How do I track the status of my order?

You will receive an email with your tracking number after you place an order.

19 reviews for Fortifeye Next Gen Zinc Free Macular Defense Capsules

  1. Leeann Jacoby (verified owner)

    You are always friendly and professional. I receive the product quickly and efficiently. I would recommend you to anyone.

  2. Sylvester Makowski (verified owner)

  3. Leeann Jacoby (verified owner)

    Just what I ordered and arrived very quickly. Thank you

  4. Leeann Jacoby (verified owner)

    iT’S A GOOD PRODUCT. And you concur snail mail.

  5. Paul

    Wow, this is brand new. Looks like an amazing formula for macular degeneration. I will get my mom on it asap and i will take maybe one or two a day for prevention.

  6. Kathy Mondello (verified owner)

  7. Anonymous (verified owner)

  8. Carol B. (verified owner)

    I hope they are helping with my MD. Quite expensive.

  9. Paul (verified owner)

  10. Lane Pelletier (verified owner)

    Just got this and just started taking it…so…I can’t yet give a proper review as to how it’s working.

  11. Bob (verified owner)

  12. Sylvester (verified owner)

  13. Anonymous (verified owner)

  14. Anonymous (verified owner)

    I have been using MD Capsules with zink. Missed that on the order……my bad. Simply solved. Bought a bottle of zink.

  15. Anonymous (verified owner)

  16. Marsha B. (verified owner)

  17. Walter (verified owner)

  18. Susan B. (verified owner)

  19. Susan (verified owner)

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