Whether your goal is peak performance in the gym, faster recovery, or maintaining strength and vitality as you age, the right nutrition is key. Three of the most research-backed nutrients—Creapure® Creatine, myHMB®, and Vitamin D3—work together to fuel your body, support muscle health, and sustain optimal energy.
Creapure® Creatine doesn’t just fuel your muscles—it fuels your mind. By supporting energy production in the brain, it helps sharpen focus, improve memory under stress, and may protect against age-related cognitive decline.
$39.99 — available on subscription
Fortifeye® Creapure® Creatine + myHMB® + Vitamin D3 is an advanced, physician-formulated supplement designed to support muscle strength, endurance, recovery, brain energy, and bone health at any age. This unflavored, easy-to-mix powder combines three clinically researched, trademarked ingredients that work synergistically to build and preserve lean muscle while supporting overall vitality. Whether training hard, staying active, or navigating the natural aging process, this formula helps promote strength, resilience, and performance. It is free from proprietary blends, sweeteners, and artificial flavors, with fully transparent dosing you can trust. Appropriate for any adult, with no upper age limit.
Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?Authors: Jose Antonio1* , Darren G. Candow2 , Scott C. Forbes3 , Bruno Gualano4 , Andrew R. Jagim5 , Richard B. Kreider6 , Eric S. Rawson7 , Abbie E. Smith-Ryan8 , Trisha A. VanDusseldorp9 , Darryn S. Willoughby10 and Tim N. Ziegenfuss11
volume 18, Article number: 13 (2021)
Journal of the International Society of Sports Nutrition
https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00412-w
Creatine for Life: in Health, Sport and Medicine
Issue Editors: Theo Wallimann, Roger Harris
Amino Acids All Volumes & Issues
Volume 48, Issue 8, August 2016
https://link.springer.com/
Creatine: a miserable life without it
Theo Wallimann & Roger Harris
Editorial Published: 15 July 2016
Amino Acids volume 48, pages 1739–1750(2016)
https://link.springer.com/
The creatine kinase system and pleiotropic effects of creatine
Theo Wallimann, Malgorzata Tokarska-Schlattner & Uwe Schlattner
Invited Review Open Access Published: 30 March 2011
Amino Acids volume 40, pages 1271–1296(2011)
https://link.springer.com/
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasis.
T Wallimann, M Wyss, D Brdiczka, K Nicolay, and H M Eppenberger
Biochem J. 1992 Jan 1; 281(Pt 1): 21–40.
https://www.ncbi.nlm.nih.gov/
Entire list of publications by Prof. Dr. Theo Wallimann
http://publicationslist.org/
Kreider, R. B., Kalman, D.S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D.G., Kleiner, S. M., Almada, A. L. & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. https://jissn.biomedcentral.com/track/pdf/10.1186/s12970-017-0173-z
Thomas, D.T.; Erdman, K.A.; Burke, L.M., Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance, J.Acad.Nutr.Diet. (2016), 116 (3), S. 501 – 528 https://www.sciencedirect.com/science/article/pii/S221226721501802X?viewFullText=true
Terjung RL, Clarkson P, Eichner ER, Greenhaff PL, Hespel PJ, Israel RG, Kraemer WJ, Meyer RA, Spriet LL, Tarnopolsky MA, Wagenmakers AJ and Williams MH, 2000. American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation. Medicine and Science in Sports and Exercise, 32, 706-717.https://journals.lww.com/acsm-msse/Fulltext/2000/03000/Physiological_and_Health_Effects_of_Oral_Creatine.24.aspx
Effect of dietary supplements on lean mass and strength gains with resistance exercise: A meta-analysis. Nissen, S.L.; Sharp, R.L. (2003), 94 (2), S. 651 – 659 https://www.physiology.org/doi/full/10.1152/japplphysiol.00755.2002
Effect of creatine supplementation on body composition and performance: a meta-analysis Branch, J.D. Int.J.Sport Nutr.Exerc.Metabol. (2003), 13 (2), S. 198 – 226 https://www.ncbi.nlm.nih.gov/pubmed/12945830
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Scientific Opinion on the substantiation of health claims related to creatine and increase in physical performance during short‐term, high intensity, repeated exercise bouts (ID 739, 1520, 1521, 1522, 1523, 1525, 1526, 1531, 1532, 1533, 1534, 1922, 1923, 1924), increase in endurance capacity (ID 1527, 1535), and increase in endurance performance (ID 1521, 1963) pursuant to Article 13(1) of Regulation (EC) No 1924/2006, EFSA Journal 2011;9(7): 2303. https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2011.2303
Volek, J.S., Duncan, N. D., Mazzetti, S. A., Staron, R. S., Putukian, M., Gomez, A. L., Pearson, D.R., Fink, W.J. & Kraemer, W.J. (1999). Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Medicine and Science in Sports and Exercise, 31, 1147–1156. https://journals.lww.com/acsm-msse/Fulltext/1999/08000/Performance_and_muscle_fiber_adaptations_to.11.aspx
Brenner, M., Walberg Rankin, J. & Sebolt, D. (2000). The effect of creatine supplementation during resistance training in women. Journal of Strength and Conditioning Research, 14, 207–213. https://journals.lww.com/nsca-jscr/abstract/2000/05000/the_effect_of_creatine_supplementation_during.15.aspx
Vandenberghe, K., Goris, M., van Hecke, P., van Leemputte, M., Vangerven, L. & Hespel, P. (1997). Long-term creatine intake is beneficial to muscle performance during resistance training. Journal of Applied Physiology, 83, 2055–2063. https://www.physiology.org/doi/full/10.1152/jappl.1997.83.6.2055
Enette Larson-Meyer, D., Hunter, G. R., Trowbridge, C. A., Turk, J. C., Ernest, J. M., Torman, S. L. & Harbin, P.A. (2000). The effect of creatine supplementation on muscle strength and body composition during off-season training in female soccer players. Journal of Strength and Conditioning Research, 14, 434–442. https://journals.lww.com/nsca-jscr/Abstract/2000/11000/The_Effect_of_Creatine_Supplementation_on_Muscle.11.aspx#pdf-link
Arciero, P.J., Hannibal 3rd, N.S., Nindl, B.C., Gentile, C. L., Hamed, J . & Vukovich, M.D. (2001). Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow. Metabolism, 50, 1429–1434. https://www.metabolismjournal.com/article/S0026-0495(01)80994-X/pdf
Willoughby, D. S. & Rosene, J. (2001). Effects of oral creatine and resistance training on myosin heavy chain expression. Medicine and Science in Sports and Exercise, 33, 1674–1681.https://journals.lww.com/acsm-msse/Fulltext/2001/10000/Effects_of_oral_creatine_and_resistance_training.10.aspx#pdf-link
Haff, G. G., Kirksey, K. B., Stone, M. H., Warren, B.J.Johnson, R. L., Stone, M., O’Bryant, H. & Proulx, C. (2000). The effect of 6 weeks of creatine monohydrate supplementation on dynamic rate of force development. Journal of Strength and Conditioning Research, 14 (4), 426–433. https://journals.lww.com/nsca-jscr/abstract/2000/11000/the_effect_of_6_weeks_of_creatine_monohydrate.10.aspx#pdf-link
Ostojic, S. M. (2004). Creatine supplementation in young soccer players. International Journal of Sport Nutrition and Exercise Metabolism, 14, 95–103. https://pdfs.semanticscholar.org/8552/c8dde9ca0db3efaee0abd93babbd98fafe80.pdf?_ga=2.46015520.566837585.1563266315-1959673618.1563266315
Cox, G., Mujika, I., Tumilty, D. & Burke, L. (2002). Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. International Journal of Sport Nutrition and Exercise Metabolism, 12, 33–46. http://www.humankinetics.com/acucustom/sitename/Documents/DocumentItem/606.pdf
Mohebbi, H., Rahnama, N., Moghadassi, M. & Ranjbar, K. (2012). Effect of creatine supplementation on sprint and skill performance in young soccer players. Middle-East Journal of Scientific Research, 12 (3), 397–401. https://pdfs.semanticscholar.org/2fd0/dd0909210c0406e1648b51019521d5089f9d.pdf
Mujika, I., Padilla, S., Ibanez,J., Izquierdo, M. & Gorostiaga, E. (2000). Creatine supplementation and sprint performance in soccer players. Medicine and Science in Sports and Exercise, 32 (2), 518–525. http://www2.unavarra.es/gesadj/depCSalud/mikel_izquierdo/creatinamujika.pdf
Havenetidis, K., Cooke, C., King, R. & Denison, T. (1996). Repeated creatine supplementation and swimming performance. Abstracts of the 1st Annual Congress of the European College of Sport Science, 566–567. https://pmc.ncbi.nlm.nih.gov/articles/PMC3818661/
Selsby, J.T., Beckett, K. D., Kern, M. & Devor, S.D. (2003). Swim performance following creatine supplementation in division III athletes. Journal of Strength and Conditioning Research, 17,421–424. https://journals.lww.com/nsca-jscr/Abstract/2003/08000/Swim_Performance_Following_Creatine.1.aspx
Peyrebrune, M. C., Nevill, M. E., Donaldson, F.J. & Cosford, D.J. (1998). The effects of oral creatine supplementation on performance in single and repeated sprint swimming. Journal of Sports Sciences, 16, 271–279. https://www.tandfonline.com/doi/abs/10.1080/026404198366803
Theodorou, A. S., Cooke, C.B., King, R. F. G.J., Hood, C., Denison, T., Wainwright, B. G. & Havenetidis, K. (1999). The effect of longer-term creatine supplementation on elite swimming performance after an acute creatine loading. Journal of Sports Sciences, 17, 853–859. https://www.tandfonline.com/doi/abs/10.1080/026404199365416
Ziegenfuss, T. N., Rogers, M., Lowery, L., Mullins, N., Mendel, R., Antonio, J. & Lemon, P. (2002). Effect of creatine loading on anaerobic performance and skeletal muscle volume in NCAA division I Athletes. Nutrition, 18(5), 397–402. https://www.sciencedirect.com/science/article/pii/S0899900701008024?viewFullText=true
Santos, R.V., Bassit, R.A., Caperuto, E. C. & Costa Rosa, L. F. (2004). The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30km race. Life Sciences, 75, 1917–1924. https://www.sciencedirect.com/science/article/pii/S0024320504005211?viewFullText=true
Volek, J.S., Mazzetti, S.A., Farquhar, W. B., Barnes, B. R., Gomez, A. L. & Kraemer, W.J. (2001). Physiological responses to short-term exercise in the heat after creatine loading. Medicine and Science in Sports and Exercise, 33, 1101 –1108. https://journals.lww.com/acsm-msse/Fulltext/2001/07000/Physiological_responses_to_short_term_exercise_in.6.aspx
Johnston, A. P., Burke, D. G., MacNeil, L. G. & Candow, D. G. (2009). Effect of creatine supplementation during cast-induced immobilization on the preservation of muscle mass, strength, and endurance. Journal of Strength and Conditioning Research, 23, 116–120. https://journals.lww.com/nsca-jscr/fulltext/2009/01000/Effect_of_Creatine_Supplementation_During.19.aspx
Rahimi, R. (2011). Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. Journal of Strength and Conditioning Research, 25, 3448–3455. https://journals.lww.com/nsca-jscr/fulltext/2011/12000/Creatine_Supplementation_Decreases_Oxidative_DNA.29.aspx#pdf-link
The effects of creatine supplementation and physical exercise on traumatic brain injury
Freire Royes, L.F.; Cassol, G.
Mini Rev.Med.Chem. (2015), 16 (1), S. 29 – 39
https://www.ingentaconnect.com/content/ben/mrmc/2016/00000016/00000001/art00007
Clark, B. C. & Manini, T. M. (2010). Functional Consequences of Sarcopenia and Dynapenia in the Elderly. Current Opinion in Clinical Nutrition and Metabolic Care, 13 (3), 271 –276. https://journals.lww.com/co-clinicalnutrition/Abstract/2010/05000/Functional_consequences_of_sarcopenia_and.11.aspx
Ethgen, O., Beaudart, C., Buckinx, F., Bruyère, O. & Reginster, J. Y. (2017). The Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action. Calcified Tissue International, 100 (3), 229–234. https://link.springer.com/content/pdf/10.1007%2Fs00223-016-0220-9.pdf
MacDougall, J. D., Ward, G. R., Sale, D. G. & Sutton, J. R. (1977). Biochemical adaptation of human skeletal muscle to heavy resistance training and immobilization. Journal of Applied Physiology, 43, 700–703. https://www.physiology.org/doi/abs/10.1152/jappl.1977.43.4.700
Cruz-Jentoft, A.J., Baeyens, J . P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J. P., Rolland, Y., Schneider, S. M., Topinkova, E., Vandewoude, M. & Zamboni, M. (2010). Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age and Ageing, 39 (4), 412–423. https://academic.oup.com/ageing/article/39/4/412/8732
Devries, M. C. & Phillips, S. M. (2014). Creatine supplementation during resistance training in older adults-a meta-analysis. Medicine and Science in Sports and Exercise, 46, 1194–1203. https://journals.lww.com/acsm-msse/fulltext/2014/06000/Creatine_Supplementation_during_Resistance.16.aspx#pdf-link
Chilibeck, P. D., Chrusch, M.J., Chad, K. E., Davison, K. S. & Burke, D. G. (2005). Creatine monohydrate and resistance training increase bone mineral content and density in older men. Journal of Nutrition Health and Aging, 9 (5), 352–355. https://www.researchgate.net/publication/7544643_Creatine_monohydrate_and_resistance_training_increase_bone_mineral_content_and_density_in_older_men
Chrusch MJ, Chilibeck PD, Chad KE, Davison KS and Burke DG, 2001. Creatine supplementation combined with resistance training in older men. Medicine and Science in Sports and Exercise, 33, 2111-2117. https://journals.lww.com/acsm-msse/Fulltext/2001/12000/Creatine_supplementation_combined_with_resistance.21.aspx
Pinto, C. L., Botelho, P. B., Carneiro, J. A. & Mota, J.F. (2016). Impact of creatine supplementation in combination with resistance training on lean mass in the elderly. Journal of Cachexia, Sarcopenia and Muscle, 7 (4), 413–421. https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.12094
Pinto, C. L., Botelho, P. B., Carneiro, J. A. & Mota, J.F. (2016). Impact of creatine supplementation in combination with resistance training on lean mass in the elderly. Journal of Cachexia, Sarcopenia and Muscle, 7 (4), 413–421. https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.12094
Wallimann,T. (2014). Positive Wirkung von Kreatin im Alter und für Rehabilitation. Schweizer Zeitschrift für Ernährungsmedizin, 1, 31 –32. https://www.researchgate.net/publication/264043408_Positive_Wirkung_von_Kreatin_im_Alter_und_fur_Rehabilitation
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2016). Scientific opinion on creatine in combination with resistance training and improvement in muscle strength: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal, 14 (2), 4400. https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2016.4400
Chilibeck, P. D., Chrusch, M.J., Chad, K. E., Davison, K. S. & Burke, D. G. (2005). Creatine monohydrate and resistance training increase bone mineral content and density in older men. Journal of Nutrition Health and Aging, 9 (5), 352–355. https://www.researchgate.net/publication/7544643_Creatine_monohydrate_and_resistance_training_increase_bone_mineral_content_and_density_in_older_men
Chilibeck, P.D., Candow, D.G., Landeryou, T., Kaviani, M. & Paus-Jenssen, L. (2015). Effects of creatine and resistance training on bone health in postmenopausal women. Medicine and Science in Sports and Exercise, 47 (8), 1587–1595. https://journals.lww.com/acsm-msse/fulltext/2015/08000/Effects_of_Creatine_and_Resistance_Training_on.5.aspx
Gualano, B., de Salles Painneli, V., Roschel, H., Artioli, G. G., Neves, M. Jr., de Sá Pinto, A. L., da Silva, M. E., Cunha, M.R., Otaduy, M.C., Leite, Cda C., Ferreira, J. C., Pereira, R. M., Brum, P.C., Bonfá, E. &Lancha, A. H. Jr. (2010). Creatine in Type 2 Diabetes: a randomized, double-blind, placebo-controlled trial. Medicine and Science in Sports and Exercise, 43 (5), 770–778. https://journals.lww.com/acsm-msse/fulltext/2011/05000/Creatine_in_Type_2_Diabetes__A_Randomized,.5.aspx
Dechent, P., Pouwels, P.J. W., Wilken, B., Hanefeld, F. &Frahm,J. (1999). Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 277, R698-R704. https://www.physiology.org/doi/pdf/10.1152/ajpregu.1999.277.3.R698
Sappey-Marinier, D., Calabrese, G., Fein, G., Hugg, J.W., Biggins, C. & Weiner, M.W. (1992). Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism, 12, 584–592. https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1992.82
Creatine supplementation, sleep deprivation, cortisol, melatonin and behavior
McMorris, T.; Howard, A.N.; Langridge, G.; Hall, B.; Corbett, J.; Dicks, M.; Hodgson, C.; Harris, R.C.
Physiol.Behav. (2007), 90 (1), S. 21 – 28
https://www.sciencedirect.com/science/article/pii/S0031938406003763?viewFullText=true
Creatine supplementation and cognitive performance in elderly individuals.
McMorris, T.; Harris, R.C.; Swain, J.P.; Howard, A.; Mielcarz, G.
Aging Neuropsychol.Cogn. (2007), 14 (5), S. 517 – 528
https://www.tandfonline.com/doi/abs/10.1080/13825580600788100
Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol Category Original Investigation
McMorris, T.; Swain, J.P.; Corbett, J.; Collard, K.; Dyson, R.J.; Dye, L.; Hodgson, C.; Draper, N.; Harris, R.C.
Psychopharmacol. (2006), 185 (1), S. 93 – 103
https://link.springer.com/article/10.1007%2Fs00213-005-0269-z
Rae, CD.; Broeer, S., Creatine as a booster for human brain function. How might it work?, Neurochem.Int. (2015), 89 (), S. 249 – 259. https://www.sciencedirect.com/science/article/pii/S0197018615300383?viewFullText=true
TSI Group’s official site houses a substantial collection of studies, organized by year and focus. Among the highlighted investigations:
**2020 NIH-Funded Double-Blind Study**
Title: Long‑term Effects of Calcium β‑Hydroxy‑β‑Methylbutyrate and Vitamin D₃ on Muscular Function (12‑month RCT in adults ≥60 years)
Key Findings: In non‑exercising older adults, HMB + Vitamin D₃ significantly increased lean mass, improved knee extension torque, and elevated a functional physical index at 3, 6, and 12 months. myHMB® Wikipedia myHMB®
2021 Postoperative Immobilization Study
Explored CaHMB + Vitamin D + protein supplementation for recovery in malnourished older adults post–hip fracture. myHMB®
2021 Handgrip Strength in Elderly Patients
Investigated an enteral HMB + Vitamin D supplement’s effect on quality of life and grip strength in a cohort with an average age of ~79. myHMB®
2020 Time‑Restricted Feeding + Resistance Training (Women)
Randomized trial in active females assessing HMB’s impact when combined with an 8‑week time‑restricted feeding program. myHMB®
2019 Open‑Label RCT in Women Over 65
Studied oral HMB supplementation’s effect on physical performance in older women. Wikipedia myHMB®
2019 Systematic Review & Meta‑Analysis
Synthesized 15 RCTs assessing HMB’s impact on skeletal muscle mass and physical function; concluded that HMB and HMB‑containing supplements increase muscle mass and strength. myHMB®
2018 Studies in Athletes
Included a pre‑exercise HMB free‑acid dose (3 g) study in men for work capacity recovery, and broader reviews of HMB supplementation in trained vs. untrained individuals. TSI Group myHMB® Wikipedia
2017 Athlete‑Focused Research
Examined HMB’s effects on aerobic capacity and body composition in trained combat athletes. myHMB®
2017 Muscle Protein Metabolism Study
Explored CaHMB’s effects on muscle protein synthesis and breakdown in young males. myHMB®
April 2025 — Frontiers in Nutrition Meta‑Analysis
Evaluated 21 RCTs (1,935 participants aged 50+) and found HMB (3 g/day for at least 12 weeks) significantly improves muscle mass, strength, and physical function. myHMB® TSI Group myHMB®
2025 — Nutrients Review
Reviewed HMB’s role within nutritional strategies for sarcopenia, highlighting its mechanisms—protein synthesis stimulation, inflammation reduction, and oxidative stress mitigation—and practical necessity of supplementation. TSI Group Wikipedia
January 2025 — ISSN Updated Position Stand
The International Society of Sports Nutrition released a comprehensive evidence-based position stand reaffirming HMB’s safety (up to 1 year) and its benefits across recovery, body composition, strength, aerobic performance, and healthy aging—including synergies with creatine, Vitamin D, protein, and specific amino acids. myHMB® Wikipedia
2023 — 12-Week RCT in Sarcopenic Adults
Published in the Journal of Nutrition, Health & Aging, this double-blind RCT in adults over 60 with sarcopenia found HMB significantly enhanced resistance training effects on strength, performance, muscle quality, and lowered inflammatory markers. myHMB® Wikipedia
1999 Kreider et al. Study (Int J Sports Med)
Double-blind RCT on resistance-trained men (3-6 g HMB daily for 28 days) observed no significant improvements in body composition or strength—highlighting mixed results in experienced athletes. PubMed
PMC Review on HMB Efficacy
Reviews exist discussing studies that both support and conflict with HMB’s efficacy, acknowledging some inconsistent results. PMC
General Biological Insights (Wikipedia summary)
HMB has extensive clinical support for enhancing muscle size, strength, reducing exercise-induced damage, aiding recovery, and helping preserve muscle in age-related loss. Metabolic mechanisms include stimulating protein synthesis and reducing breakdown, with no reported adverse effects up to 3 g/day for a year. Wikipedia
| Study Type / Focus | Key Findings |
|---|---|
| NIH‑funded RCT (2020) | HMB + Vitamin D improved muscle function/mass in older adults, even without exercise |
| Post‑Hip Fracture Recovery (2021) | Enhanced recovery outcomes in malnourished elderly |
| Handgrip & QoL in Elderly (2021) | Improved strength and quality of life in very old cohort |
| Time‑Restricted Feeding (2020) | Explored HMB effects during dietary timing and training |
| Older Women RCT (2019) | Boosted physical performance in women >65 |
| Meta‑Analysis of RCTs (2019) | HMB increases muscle mass & strength |
| Athlete & Metabolic Studies (2017–2018) | Mixed results; benefits seen in untrained or specific contexts |
| Frontiers in Nutrition Meta‑Analysis (2025) | Robust evidence for aging populations |
| Nutrients Review (2025) | Supports HMB in sarcopenia nutritional strategies |
| ISSN Position Stand (2025) | Comprehensive evidence, safety affirmed, synergistic benefits |
| RCT in Sarcopenic Adults (2023) | Improved training outcomes and reduced inflammation |
| Early Kreider et al. (1999) | Limited impact in experienced athletes |
| Reviews on conflicting evidence | Acknowledges mixed or inconclusive results in some cases |
| Biological mechanism synthesis | Highlights the dual anabolic and anti‑catabolic pathways |
Scoop in shaker and shake with spring water or favorite beverage. Can be blended with favorite fruits or vegetables to make a smoothie.
Mix or shake it with water or any beverage of choice.
Enjoy the flavor and health benefits of Fortifeye!
Fortifeye Creatine + myHMB® + Vitamin D is a science-based muscle, strength, and longevity formula designed to:
It combines three clinically studied ingredients:
Most creatine products on the market:
Fortifeye is different.
We use:
👉 The reality is: most companies do NOT use Creapure® because of the higher cost.
We choose it anyway—because quality matters.
Not all creatine is created equal.
Creapure® offers:
Lower-quality creatine can contain unwanted byproducts, while Creapure® is known for its clean, reliable profile.
👉 This is one of the biggest reasons Fortifeye stands apart.
Creatine is one of the most researched supplements in the world and may:
myHMB® is a metabolite of leucine that plays a key role in muscle health.
It may:
Yes—but indirectly and more effectively than most “fat burners.”
myHMB® helps improve body composition, meaning:
👉 This is critical because muscle drives metabolism.
1. Preserves Lean Muscle
Prevents muscle loss during:
2. Improves Body Composition
Research shows HMB can:
Even when the scale doesn’t change dramatically, the mirror does.
3. Enhances Workout Performance
➡️ Leads to greater calorie burn and fat loss over time
4. Supports Metabolism & Aging
Helps maintain muscle as we age, which:
Why is Vitamin D included?
Many people are deficient, limiting performance and recovery.
Ideal for:
Yes—this is a major use case.
Medications like Ozempic and Wegovy can lead to:
Fortifeye Creatine + myHMB® helps:
No—and that’s actually a good thing.
Unlike stimulant fat burners, this formula:
👉 Think: “Lose fat. Keep muscle.”
Creatine pulls water into muscle cells, not under the skin.
Results:
High-quality creatine like Creapure® minimizes unwanted side effects.
Yes.
Yes.
Modern research shows no meaningful interference with creatine absorption.
You can mix it with:
👉 Consistency matters more than timing.
Absolutely:
Yes.
Creatine has been shown to support:
No.
There is no need to cycle creatine or HMB. Daily use is optimal.
Not just good—essential.
Helps:
Absolutely.
Benefits include:
Fortifeye Creatine + myHMB® + Vitamin D is a next-generation performance and longevity formula designed to:
✔ Build and preserve muscle
✔ Enhance strength and recovery
✔ Improve fat loss through better body composition
✔ Support brain, bone, and metabolic health
👉 And unlike most products, it uses Creapure®—the purest and most trusted form of creatine available.
Typical shipping for USPS packages are 4-6 business days. International and large shipments may vary in shipment time. Free shipping only applies to United States shipments. Free shipping promotions does not apply to international orders.
At Fortifeye we offer full refund if not satisfied with product purchased. Refunds are only applicable for price paid for product, shipping charges are not refundable. We are also not responsible for shipping cost to return product to the address below unless the product was received damaged or the wrong product was received for the order placed. We ask that Returns meet the following requirements:
You will receive an email with your tracking number after you place an order.
Building and maintaining strong muscle, bone, and brain health requires more than exercise alone—it depends on proper nutrition. This formula is designed to complement a balanced diet rich in protein, micronutrients, and healthy fats. Creatine supports cellular energy availability, myHMB® supports muscle protein balance, and Vitamin D3 supports nutrient absorption and musculoskeletal health. When combined with adequate protein intake and resistance training, this supplement supports whole-body performance and long-term wellness. It fits seamlessly into daily nutrition routines without added sugars, flavors, or fillers.
Myostatin (GDF-8) is a natural protein in the body that acts as a regulator of muscle growth. Think of it as a “brake pedal” that limits how much muscle your body can build.
While this mechanism keeps muscle mass in check, elevated myostatin levels—which often occur with aging, inactivity, and stress—can accelerate muscle loss (sarcopenia) and make it harder to maintain strength, energy, and mobility.
Fortifeye’s innovative blend of Creapure® Creatine, myHMB®, and Vitamin D3 was developed to help counteract the effects of myostatin naturally and promote lean muscle growth, endurance, and recovery:
myHMB® (β-Hydroxy β-Methylbutyrate): Research suggests HMB can help reduce myostatin expression while stimulating muscle protein synthesis, protecting muscle tissue from breakdown.
Creapure® Creatine: Supports cellular energy and strength, helping muscles perform better and recover faster—further complementing the anti-myostatin effects of HMB.
Vitamin D3: Optimal vitamin D status has been linked to lower myostatin levels and better muscle tone, strength, and coordination.
By supporting natural pathways that inhibit myostatin and enhance muscle repair, the Fortifeye Creatine + myHMB + Vitamin D supplement helps you:
Build and preserve lean muscle mass
Boost strength and endurance
Enhance metabolic function and recovery
Combat age-related muscle decline
This physician-formulated trio gives your body the tools to release the brake on muscle growth—helping you stay active, strong, and vibrant at any age.
Muscle, brain, and bone health are deeply interconnected, especially as we age. Creatine plays a critical role in brain energy metabolism, supporting focus, memory, and cognitive resilience during physical or mental stress. Vitamin D3 contributes to neurological signaling while also supporting bone mineralization and structural strength. By enhancing muscle force output, creatine indirectly supports bone health through beneficial mechanical loading, while myHMB® helps maintain muscle integrity that protects skeletal stability.
This formula is also uniquely suited for individuals pursuing weight loss. During caloric restriction or GLP-1–based therapies, maintaining lean muscle is essential for metabolic health. Fortifeye® Creatine + myHMB® + Vitamin D3 helps preserve lean mass, support training capacity, and promote healthy body composition—supporting strength, balance, and vitality throughout the aging process.
Releasing the Brake on Muscle Growth
As we age, muscle protein breakdown often begins to outpace muscle growth, partly due to elevated myostatin levels—a natural regulator that limits muscle development. Fortifeye® Creatine + myHMB® + Vitamin D3 is designed to support the body’s natural muscle-building pathways while helping counteract this age-related slowdown. Creatine supports ATP availability, allowing for greater training intensity and strength output. myHMB® helps preserve muscle tissue by reducing breakdown and supporting protein synthesis. Vitamin D3 supports muscle fiber activation and neuromuscular signaling, helping maintain strength, mobility, and independence over time.
Together, these ingredients promote lean muscle preservation, strength development, and recovery when combined with resistance training and adequate protein intake. This makes the formula ideal not only for athletes, but also for active adults focused on long-term physical function and healthy aging.
Fortifeye® Creapure® Creatine + myHMB® + Vitamin D3 is a comprehensive, science-backed supplement designed for adults seeking strength, resilience, and vitality at every stage of life. It supports muscle development, brain energy, bone health, recovery, and healthy weight management—while addressing key challenges associated with aging, such as muscle loss, reduced strength, and declining mobility. Ideal for athletes, active adults, older individuals, and those managing body composition or weight loss, this formula helps preserve lean muscle and support long-term independence. With no upper age limit, it is designed to help you stay strong, sharp, and active—now and for years to come.
Michael Young (verified owner) –
Tony –
I have been using this supplement ever since it came out over a year ago and I can honestly say it has helped my strength in my workouts considerably. I have also gained significant muscle size in the same period of time. I just picked up the Fortifeye Fit Meal and I will be adding the creatine/myHMB to the fit meal for the perfect muscle fuel. Thanks to Dr Langes radio program I have really improved my health.
Taylor Moncado (store manager) –
Great to hear! We hope you enjoy the products and continue tuning in to the radio show!
Bradley –
My trainer recommended this brand and in less than a month I have already noticed considerable strength and muscle gains
Sally –
Thanks to Dr Langes radios show “ask the dr” I now know the difference between good and not so good creatine. I have my 18 yo son and myself taking this supplement now. We are avid water ski competitors and hoping this will help with strength and recovery. I will report back the benefits after using it for a few months.
Gayle –
After one month I noticed improvement in muscle tone and strength and I have lost six pounds . I have a lot more energy doing palates and yoga too.
Stanley S. (verified owner) –
Eddie R –
Creapure Creatine is the most studied , best creatine on the planet. The combination of this with myHMB and Vitamin d is perfect for building muscle and burring off fat. I will change to this brand.
Mark Parker –
My 95 yo mother and I have both been taking this Creatine/ MyHMB supplement for about 3 months now and it works! My body fat is down, muscle tone and strength are way up. I mix it with Fortifeye Vegan Super Protein before or after working out and my mom has it in her orange juice every am. Mom seems to be able to get up much faster after sitting for a while without my help. Thanks Fortifeye!